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The Raelian Movement
for those who are not afraid of the future : http://www.rael.org
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Revealed: how vitamin D can protect us from cancer
Scientists discover how substance controls actions of genes
By Steve Connor, Science Editor
Tuesday, 24 August 2010
Vitamin D protects the body against a range of serious illnesses by binding to the DNA of the body's cells and directly controlling the genes implicated in diseases such as multiple sclerosis, diabetes and cancer, a study suggests.
It is the first time that scientists have found direct evidence to suggest that the "sunshine vitamin", which is made by the skin in the presence of sunlight, directly controls a network of genes linked with a wide variety of serious disorders.
Although previous studies have linked vitamin D deficiency with a growing list of illnesses, especially the autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and type-1 diabetes, until now scientists have not been able to show how it could trigger so many different disorders.
The latest study suggests a possible mechanism by showing that vitamin D binds directly to parts of the human genome that house the genes known to be linked with these serious autoimmune disorders, which result from a person's immune system attacking the body's own tissues.
"A surprisingly large number of genes that have been highlighted by gene-associated studies in autoimmunity and cancer seem to be regulated by vitamin D," said Professor George Ebers, a clinical neurologist at the Radcliffe hospital in Oxford.
"This is indirect, but intriguing evidence that vitamin D will prove to be a major player in the key gene-environment interactions that expose us to diseases," Professor Ebers said.
It is estimated that a billion people in the world could be suffering from deficiencies in vitamin D, which can be ingested in the diet in small amounts but is primarily produced by the skin when exposed to direct sunlight, so the findings could have major health implications for people living in northern latitudes with low levels of sunlight.
The researchers, funded by the Wellcome Trust, analysed human cells that had been stimulated by the active form of vitamin D. They found that the vitamin D receptor protein bonded to a total of 2,776 sites along the DNA of the genome. They also found that the vitamin had a significant effect on altering the activity of 229 genes located near to these sites.
"We screened the whole genome and found all the sites where vitamin D binds. The evidence is now quite solid that not only is there binding but we've been able to show that it actually affects the functioning of the gene. It's not just sticking to that region, it's actually altering gene expression," Professor Ebers said.
"We show there's an excess of genes that are associated with a bunch of autoimmune conditions that seem to have the vitamin D regulation feature. I don't think we can say [this is] cause and effect, but it's not a coincidence. It is clearly not there by chance. There's a very substantial bias among these genes that have been highlighted as playing a role in these autoimmune conditions, and that have turned out to be regulated by vitamin D," he explained.
If the study, published in the journal Genome Research, is supported by further research it could explain why vitamin D plays such an important role in a wide spectrum of diseases and why people who are native to northern latitudes have over many generations evolved a white skin, which absorbs sunlight more efficiently than darker skin.
"Vitamin D status is potentially one of the most powerful selective pressures on the genome in relatively recent times. Our study appears to support this interpretation and it may be we have not had enough time to make all the adaptations we have needed to cope with our northern circumstances," Professor Ebers said.
Sreeram Ramagopalan, of the Wellcome Trust Centre for Human Genetics at Oxford University, said the findings suggest vitamin D supplements may be important. "Vitamin D supplements during pregnancy and the early years could have a beneficial effect on a child's health in later life," he said.
Three ways to get your fix
*Vitamin D is produced naturally by the skin but only in the presence of sunlight. Sunshine contains ultraviolet light B (UVB) which converts a ubiquitious precursor substance in the skin, called 7-dehydrocholesterol, into vitamin D3. This can then be converted by the liver and kidneys into the biologically active form of vitamin D.
The vitamin is also present in relatively high amounts in fish and shellfish, and in lower amounts in eggs and dairy produce. By far the easiest and best way of delivering enough vitamin D to the body is to expose unprotected skin to direct sunlight for a few minutes each day. But light-skinned people are advised not to burn their skin.
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WARNING FROM RAEL: For those who don't use their intelligence at its full capacity, the label "selected by RAEL" on some articles does not mean that I agree with their content or support it. "Selected by RAEL" means that I believe it is important for the people of this planet to know about what people think or do, even when what they think or do is completely stupid and against our philosophy. When I selected articles in the past about stupid Christian fundamentalists in America praying for rain, I am sure no Rael-Science reader was stupid enough to believe that I was supporting praying to change the weather. So, when I select articles which are in favor of drugs, anti-semitic, anti-Jewish, racist, revisionist, or inciting hatred against any group or religion, or any other stupid article, it does not mean that I support them. It just means that it is important for all human beings to know about them. Common sense, which is usually very good among our readers, is good enough to understand that. When, like in the recent articles on drug decriminalization, it is necessary to make it clearer, I add a comment, which in this case was very clear: I support decriminalizing all drugs, as it is stupid to throw depressed and sad people (as only depressed and sad people use drugs) in prison and ruin their life with a criminal record. That does not mean that there is any change to the Message which says clearly that we must not use any drug except for medical purposes. The same applies to the freedom of expression which must be absolute. That does not mean again of course that I agree with anti-Jews, antisemites, racists of any kind or anti-Raelians. But by knowing your enemies or the enemies of your values, you are better equipped to fight them. With love and respect of course, and with the wonderful sentence of the French philosopher Voltaire in mind: "I disapprove of what you say, but I will defend to the death your right to say it".
"Ethics" is simply a last-gasp attempt by deist conservatives and
orthodox dogmatics to keep humanity in ignorance and obscurantism,
through the well tried fermentation of fear, the fear of science and
new technologies.
There is nothing glorious about what our ancestors call history,
it is simply a succession of mistakes, intolerances and violations.
On the contrary, let us embrace Science and the new technologies
unfettered, for it is these which will liberate mankind from the
myth of god, and free us from our age old fears, from disease,
death and the sweat of labour.
Rael
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