[rael-science] Blueberries Help Fight Artery Hardening, Lab Animal Study Indicates

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Blueberries Help Fight Artery Hardening, Lab Animal Study Indicates
http://www.sciencedaily.com/releases/2010/09/100929105701.htm

ScienceDaily (Sep. 30, 2010) — Blueberries may help fight
atherosclerosis, also known as hardening of the arteries, according to
results of a preliminary U.S. Department of Agriculture (USDA)-funded
study with laboratory mice. The research provides the first direct
evidence that blueberries can help prevent harmful plaques or lesions,
symptomatic of atherosclerosis, from increasing in size in arteries.

Principal investigator Xianli Wu, based in Little Rock, Ark., with the
USDA Agricultural Research Service (ARS) Arkansas Children's Nutrition
Center and with the University of Arkansas for Medical Sciences, led
the investigation. The findings are reported in the current issue of
the Journal of Nutrition.

Atherosclerosis is the leading cause of two forms of cardiovascular
disease--heart attacks and strokes. Cardiovascular disease is the
number one killer of Americans.

The study compared the size, or area, of atherosclerotic lesions in 30
young laboratory mice. Half of the animals were fed diets spiked with
freeze-dried blueberry powder for 20 weeks; the diet of the other mice
did not contain the berry powder.

Lesion size, measured at two sites on aorta (arteries leading from the
heart), was 39 and 58 percent less than that of lesions in mice whose
diet did not contain blueberry powder.

Earlier studies, conducted elsewhere, have suggested that eating
blueberries may help combat cardiovascular disease. But direct
evidence of that effect has never been presented previously, according
to Wu.

The blueberry-spiked diet contained 1 percent blueberry powder, the
equivalent of about a half-cup of fresh blueberries.

All mice in the investigation were deficient in apolipoprotein-E, a
trait which makes them highly susceptible to forming atherosclerotic
lesions and thus an excellent model for biomedical and nutrition
research.

Wu's group wants to determine the mechanism or mechanisms by which
blueberries helped control lesion size. For example, by boosting the
activity of four antioxidant enzymes, blueberries may have reduced the
oxidative stress that is a known risk factor for atherosclerosis.

In followup studies, Wu's group wants to determine whether eating
blueberries in infancy, childhood and young adulthood would help
protect against onset and progression of atherosclerosis in later
years. Early prevention may be especially important in light of the
nation's epidemic of childhood obesity. Overweight and obesity
increase atherosclerosis risk.

Story Source:

The above story is reprinted (with editorial adaptations by
ScienceDaily staff) from materials provided by USDA/Agricultural
Research Service, via EurekAlert!, a service of AAAS.

Journal Reference:

1. X. Wu, J. Kang, C. Xie, R. Burris, M. E. Ferguson, T. M. Badger,
S. Nagarajan. Dietary Blueberries Attenuate Atherosclerosis in
Apolipoprotein E-Deficient Mice by Upregulating Antioxidant Enzyme
Expression. Journal of Nutrition, 2010; 140 (9): 1628 DOI:
10.3945/jn.110.123927


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"Ethics" is simply a last-gasp attempt by deist conservatives and
orthodox dogmatics to keep humanity in ignorance and obscurantism,
through the well tried fermentation of fear, the fear of science and
new technologies.

There is nothing glorious about what our ancestors call history,
it is simply a succession of mistakes, intolerances and violations.

On the contrary, let us embrace Science and the new technologies
unfettered, for it is these which will liberate mankind from the
myth of god, and free us from our age old fears, from disease,
death and the sweat of labour.

Rael
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